CL-20 (8.76 g) and TNT (4.54 g) (molar ratio = 1:1) were weighed and added into an alumina jar. To it, 2 kg of 0.38 mm zirconium beads (2/3 of the cavity volume) and 200 mL of ethanol solution (volumetric ratio of ethanol and water = 1:1) were added. Then, the jar was fixed to a vertical ceramic membrane minimized ball miller.
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A cocrystal is a crystalline entity-complex formed by two (or more) different, distinct molecular entities/ingredients, which are solid at ambient temperatures, and within which the intermolecular interactions in the unique crystal lattice generated are weak forces (non-covalent and non-ionic), such as hydrogen bonds, π bonds and van der Waals
WhatsAppGet PriceGet A Quotecocrystal ASC was also prepared through Liquid Assisted Grinding (LAG). Here, LAG was performed by adding a small amount of ethanol during the grinding of the starting materials in an agate ball
WhatsAppGet PriceGet A QuoteThermal analyses of the samples were carried out on a DSC Q1000 (TA instrument) which was calibrated for temperature and enthalpy using indium. Samples (1–3 mg) were crimped in non-hermetic aluminum pans and scanned from 30 to 300°C at a heating rate of 10°C/min under a continuously purged dry nitrogen atmosphere (flow rate, 50 mL/min).
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WhatsAppGet PriceGet A QuoteThermal analyses of the samples were carried out on a DSC Q1000 (TA instrument) which was calibrated for temperature and enthalpy using indium. Samples (1–3 mg) were crimped in non-hermetic aluminum pans and scanned from 30 to 300°C at a heating rate of 10°C/min under a continuously purged dry nitrogen atmosphere (flow rate, 50 mL/min).
WhatsAppGet PriceGet A QuoteRETSCH is the world leading manufacturer of laboratory ball mills and offers the perfect product for each application. The High Energy Ball Mill E max and MM 500 were developed for grinding with the highest energy input. The innovative design of both, the mills and the grinding jars, allows for continuous grinding down to the nano range in the shortest amount of time
A cocrystal is a crystalline entity-complex formed by two (or more) different, distinct molecular entities/ingredients, which are solid at ambient temperatures, and within which the intermolecular interactions in the unique crystal lattice generated are weak forces (non-covalent and non-ionic), such as hydrogen bonds, π bonds and van der Waals
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WhatsAppGet PriceGet A QuoteBall milling was performed in a Retsch MM200 grinder for 30 minutes at a frequency of 30 Hz. The grinding was done in a metal vial with two 7 mm diameter metal balls. For liquid assisted grinding 20 μl of liquid was also added. Typically, experiments were performed on a 300 mg scale. Results Cocrystal polymorph screening by solution
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WhatsAppGet PriceGet A Quotecocrystal ASC was also prepared through Liquid Assisted Grinding (LAG). Here, LAG was performed by adding a small amount of ethanol during the grinding of the starting materials in an agate ball
WhatsAppGet PriceGet A QuoteA ball mill is a type of grinder used to grind or blend materials for use in mineral dressing processes, paints, pyrotechnics, ceramics, and selective laser sintering.It works on the principle of impact and attrition: size reduction is done by impact as the balls drop from near the top of the shell. A ball mill consists of a hollow cylindrical shell rotating about its axis. T
WhatsAppGet PriceGet A QuoteCL-20 (8.76 g) and TNT (4.54 g) (molar ratio = 1:1) were weighed and added into an alumina jar. To it, 2 kg of 0.38 mm zirconium beads (2/3 of the cavity volume) and 200 mL of ethanol solution (volumetric ratio of ethanol and water = 1:1) were added. Then, the jar was fixed to a vertical ceramic membrane minimized ball miller.
WhatsAppGet PriceGet A QuoteThe pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the chemicals to understand the physicochemical properties by particle size, size distribution, surface area, solubility, stability, porosity, thermal properties, etc. The formation of salts, solvates, and polymorphs are
WhatsAppGet PriceGet A QuoteThe formation of cocrystal imparts thermal stability to the parent compound. The melting point of the cocrystal was reported to be 120 ° C, whereas the melting point of chloral hydrate is 60 ° C. In the cocrystal, chloral betaine exists as a charge-assisted diol-carboxylate heterodimer, with further Cl ….
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WhatsAppGet PriceGet A QuoteThe formation of cocrystal imparts thermal stability to the parent compound. The melting point of the cocrystal was reported to be 120 ° C, whereas the melting point of chloral hydrate is 60 ° C. In the cocrystal, chloral betaine exists as a charge-assisted diol-carboxylate heterodimer, with further Cl ….
WhatsAppGet PriceGet A QuoteThe pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the chemicals to understand the physicochemical properties by particle size, size distribution, surface area, solubility, stability, porosity, thermal properties, etc. The formation of salts, solvates, and polymorphs are
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WhatsAppGet PriceGet A Quotecocrystal ASC was also prepared through Liquid Assisted Grinding (LAG). Here, LAG was performed by adding a small amount of ethanol during the grinding of the starting materials in an agate ball
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The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the chemicals to understand the physicochemical properties by particle size, size distribution, surface area, solubility, stability, porosity, thermal properties, etc. The formation of salts, solvates, and polymorphs are
WhatsAppGet PriceGet A QuoteThe cocrystal allows for the appropriate ali gnment of the molecules such that when the solid is photoirradiated the [2+2] photodimerizat ions occurs resulti ng in rctt-tetrakis(4pyridyl)cyclobutane.87 The cocrystal is considered by MacGillivray to be a reaction template because without the formation of the cocrystal, the olefins would not be
WhatsAppGet PriceGet A QuoteThe 5–8 mg rough lapping samples were placed in sealed aluminum pans. The DSC data were measured over the 50 °C to 350 °C at a speed of 5 °C/min. The thermogravimetry instrument (Mettler Toledo TGA/SDTA 851e module) was used to conduct TG measurements. The 8 mg grinding powder sample of cocrystal were placed in the open aluminum crucible.
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